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CD4 Antibody [GK1.5] (APC)

CD4 Antibody [GK1.5] (APC)

Item no.	PRS-76-350-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Food Safety Allergenes Neuroscience Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Clone	GK1.5
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b Kappa
Conjugate/Tag	APC
Citations	Dialynas, D. P., Quan, Z. S., Wall, K. A., Pierres, A., Quintans, J., Loken, M. R., ... Fitch, F. W. (1983). Characterization of the murine T cell surface molecule, designated L3T4, identified by monoclonal antibody GK1. 5: similarity of L3T4 to the human Leu-3/T4 molecule.The Journal of Immunology,131(5), 2445-2451. Bosselut, R., Zhang, W., Ashe, J. M., Kopacz, J. L., Samelson, L. E., Singer, A. (1999). Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction.The Journal of experimental medicine,190(10), 1517-1526. Ghobrial, R. R., Boublik, M., Winn, H. J., Auchincloss Jr, H. (1989). In Vivo use of monoclonal antibodies against murine T cell antigens.Clinical immunology and immunopathology,52(3), 486-506.
NCBI	Cd4
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	L3T4, Ly-4, Cd4
Available
Manufacturer - Isotype	Rat IgG2b, kappa
Shipping Temperature	blue ice or room temperature
Storage Conditions	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Manufacturer - Research Area	Immunology
Background	The GK1.5 monoclonal antibody specifically binds with the mouse CD4 molecule, also known as L3T4, a 55 kDa differentiation antigen which binds to the MHC class II. CD4 is expressed on most thymocytes, a subpopulation of mature T lymphocytes, dendritic cells, pluripotent hematopoietic stem cells, B cell precursors, and lymphoid precursors inside the thymus. It is also expressed on the mouse egg cell membrane, enhancing adhesion to MHC class II bearing sperm. By interaction with MHC class II on the surface of APC, CD4 initiates the development of T lymphocytes and helps the optimum functioning of mature T lymphocytes. The binding of the GK1.5 antibody blocks the binding of the Anti-Mouse CD4 RM4-5 antibody.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration	Batch dependent
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Clonality	Monoclonal
NCBI Official Name	CD4 antigen
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/4/2025

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