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CD44 Antibody [IM7]

CD44 Antibody [IM7]

Item no.	PRS-76-410-0.05mg
Manufacturer	ProSci
Amount	0.05 mg
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Breast Cancer Head & Neck Cancer Gastric Cancer
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Clone	IM7
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b Kappa
Conjugate/Tag	Unconjugated
Citations	Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues.Immunogenetics,15(3), 299-312. Lesley, J., Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein.Immunogenetics,15(3), 313-320. Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA).Journal of autoimmunity,13(1), 39-47.
NCBI	CD44
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1, CDW44, CSPG8, HCELL, HUTCH-I, ECMR-III, Ly-24, Pgp-1, HERMES, AU023126, AW121933, AW146109, CD44
Available
Manufacturer - Isotype	Rat IgG2b, kappa
Shipping Temperature	blue ice or room temperature
Storage Conditions	The product should be stored undiluted at 4°C . Do not freeze.
Manufacturer - Research Area	Functional Assays
Background	The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule.The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration	Batch dependent
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Clonality	Monoclonal
NCBI Official Name	CD44 molecule (Indian blood group)
NCBI Organism	Homo sapiens; Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 9/4/2025

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