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CD95 Antibody [EOS9.1]

CD95 Antibody [EOS9.1]

Item no.	PRS-76-567-0.05mg
Manufacturer	ProSci
Amount	0.05 mg
Category	Oncology Metabolism Diabetes Antibodies Cell Biology Cell Status Apoptosis Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody Monoclonal
Format	Liquid
Applications	FC, FA
Clone	EOS9.1
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgM Kappa
Conjugate/Tag	Unconjugated
Citations	Deaglio, S., Zubiaur, M., Gregorini, A., Bottarel, F., Ausiello, C. M., Dianzani, U., ... Malavasi, F. (2002). Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells.Blood,99(7), 2490-2498. Peruzzi, G., Femnou, L., Gil-Krzewska, A., Borrego, F., Weck, J., Krzewski, K., Coligan, J. E. (2013). Membrane-type 6 matrix metalloproteinase regulates the activation-induced downmodulation of CD16 in human primary NK cells.The Journal of Immunology,191(4), 1883-1894. Wirthmueller, U., Kurosaki, T., Murakami, M. S., Ravetch, J. V. (1992). Signal transduction by Fc gamma RIII (CD16) is mediated through the gamma chain.The Journal of experimental medicine,175(5), 1381-1390.
NCBI	FAS
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	APT1,CD95,FAS1,APO-1,FASTM,ALPS1A,TNFRSF6,FAS
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies, Functional Antibodies
Manufacturer - Isotype	Mouse IgM, kappa
Shipping Temperature	Blue Ice
Storage Conditions	The product should be stored undiluted at 4˚ C . Do not freeze.
Manufacturer - Research Area	Functional Assays
Background	The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis. It is expressed on fibroblasts, monocytes, lymphocytes, and neutrophils. CD95 induces apoptosis after binding with CD178 or Fas ligand and the EOS9.1 antibody is reported to be used for inducing apoptosis in Fas-positive cells.
By Type	Other
Modifications	None
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration	batch dependent
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Manufacturer - Specificity	The EOS9.1 monoclonal antibody specifically reacts with human CD95, a 45 kDA type I membrane molecule. CD95 is a member of the tumor necrosis factor receptor (TNF-R) family and is involved in the mechanisms that lead to cellular apoptosis.
Clonality	Monoclonal
NCBI Official Name	Fas cell surface death receptor
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.05 mg

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Delivery expected until 12/4/2025

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