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CD49d Antibody [R1-2]

CD49d Antibody [R1-2]

Item no.	PRS-76-809-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Neuroscience Neuroinflammation Aging & Neurological Disorders Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	FC, FA
Clone	R1-2
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b Kappa
Conjugate/Tag	Unconjugated
Citations	Deckert, M., Kubar, J., Zoccola, D., Bernard‐Pomier, G., Angelisova, P., Horejsi, V., Bernard, A. (1992). CD59 molecule: a second ligand for CD2 in T cell adhesion.European journal of immunology,22(11), 2943-2947. Korty, P. E., Brando, C. L. A. R. A., Shevach, E. M. (1991). CD59 functions as a signal-transducing molecule for human T cell activation.The Journal of immunology,146(12), 4092-4098. Davies, A., Simmons, D. L., Hale, G., Harrison, R. A., Tighe, H., Lachmann, P. J., Waldmann, H. (1989). CD59, an LY-6-like protein expressed in human lymphoid cells, regulates the action of the complement membrane attack complex on homologous cells.The Journal of experimental medicine,170(3), 637-654.
NCBI	Itga4
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	CD49D,Itga4B,Itga4
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies, Functional Antibodies
Manufacturer - Isotype	Rat IgG2b, kappa
Shipping Temperature	Blue Ice
Storage Conditions	The product should be stored undiluted at 4˚ C . Do not freeze.
Manufacturer - Research Area	Immunology, Functional Assays
Background	The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1). VLA-4 is expressed on thymocytes, monocytes, and a subset of peripheral lymphocytes. It is the receptor for fibronectin and CD106 (VCAM-1). CD49d also forms a receptor for mucosal vascular addressin (MAdCAM-1) with integrin beta 7.
By Type	Immunology
Modifications	None
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration	batch dependent
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Manufacturer - Specificity	The R1-2 monoclonal antibody specifically reacts with mouse CD49d (integrin alpha 4), which forms the VLA-4 complex with CD29 (integrin beta 1).
Clonality	Monoclonal
NCBI Official Name	integrin alpha 4
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 11/6/2025

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