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CD152 Antibody [UC10-4F10-11]

CD152 Antibody [UC10-4F10-11]

Item no.	PRS-76-850-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Clone	UC10-4F10-11
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., Thompson, C. B. (1996). Regulation of surface and intracellular expression of CTLA4 on mouse T cells.The Journal of Immunology,157(11), 4762-4770. Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., ... Bluestone, J. A. (1994). CTLA-4 can function as a negative regulator of T cell activation.Immunity,1(5), 405-413. Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., Holmberg, D. (1998). Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3mediated Depletion of Thymocytes.The Journal of experimental medicine,188(7), 1239-1246.
NCBI	Ctla4
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Cd152, Ly-56, Ctla-4, Ctla4
Available
Manufacturer - Isotype	Armenian Hamster IgG1, kappa
Shipping Temperature	blue ice or room temperature
Storage Conditions	The product should be stored undiluted at 4°C . Do not freeze.
Manufacturer - Research Area	Immunology
Background	The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator. The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.
Purification	The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.
Concentration	Batch dependent
Buffer	Phosphate-buffered aqueous solution, ph7.2.
Clonality	Monoclonal
NCBI Official Name	cytotoxic T-lymphocyte-associated protein 4
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 10/2/2025

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