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CD278 Antibody [ISA-3] (PE-Cy7)

CD278 Antibody [ISA-3] (PE-Cy7)

Item no.	PRS-76-969-100tests
Manufacturer	ProSci
Amount	100 tests
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Antibodies By Cell Type Hematology Lymphoma Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	Liquid
Applications	FC
Clone	ISA-3
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Conjugate/Tag	Cy7, PE
Citations	Latz, E., Schoenemeyer, A., Visintin, A., Fitzgerald, K. A., Monks, B. G., Knetter, C. F., ... Golenbock, D. T. (2004). TLR9 signals after translocating from the ER to CpG DNA in the lysosome.Nature immunology,5(2), 190-198. Leifer, C. A., Kennedy, M. N., Mazzoni, A., Lee, C., Kruhlak, M. J., Segal, D. M. (2004). TLR9 is localized in the endoplasmic reticulum prior to stimulation.The Journal of Immunology,173(2), 1179-1183. Jzsef, L., Khreiss, T., El Kebir, D., Filep, J. G. (2006). Activation of TLR-9 induces IL-8 secretion through peroxynitrite signaling in human neutrophils.The Journal of immunology,176(2), 1195-1202.
NCBI	ICOS
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	AILIM,CD278,CVID1,ICOS
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Isotype	Mouse IgG1, kappa
Shipping Temperature	Blue Ice
Storage Conditions	The product should be stored undiluted at 4˚ C and should be protected from prolonged exposure to light. Do not freeze.
Manufacturer - Research Area	Immunology
Background	The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1. It is expressed on activated T cells and a group of thymocytes and is involved in the proliferation, activation, and cytokine production of T cells. When plate-bound, the ISA-3 antibody induces the production of IL-4, 5, 10 in T cells.
By Type	Immunology
Modifications	None
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration	batch dependent
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Manufacturer - Specificity	The ISA-3 monoclonal antibody specifically reacts with human CD278 or Inducible COStimulatory molecule (ICOS), a 47-60 kDA homodimeric glycoprotein also known as H4, AILIM, and CRP-1.
Clonality	Monoclonal
NCBI Official Name	inducible T-cell co-stimulator
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 tests

available

Delivery expected until 11/6/2025

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