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CD357 Antibody [DTA-1] (APC)

CD357 Antibody [DTA-1] (APC)

Item no.	PRS-76-989-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Food Safety Drugs Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies
Type	Antibody Monoclonal
Format	liquid
Applications	FC
Clone	DTA-1
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b
Conjugate/Tag	APC
Citations	Kataoka, H., Takakura, N., Nishikawa, S., Tsuchida, K., Kodama, H., Kunisada, T., ... Nishikawa, S. I. (1997). Expressions of PDGF receptor alpha, c‐Kit and Flk1 genes clustering in mouse chromosome 5 define distinct subsets of nascent mesodermal cells.Development, growth differentiation,39(6), 729-740. Ishitobi, H., Matsumoto, K., Azami, T., Itoh, F., Itoh, S., Takahashi, S., Ema, M. (2010). Flk1-GFP BAC Tg mice: an animal model for the study of blood vessel development.Experimental animals,59(5), 615-622. Yamashita, J., Itoh, H., Hirashima, M., Ogawa, M., Nishikawa, S., Yurugi, T., ... Nishikawa, S. I. (2000). Flk1-positive cells derived from embryonic stem cells serve as vascular progenitors.Nature,408(6808), 92-96.
NCBI	Tnfrsf18
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	AITR, Gitr, Tnfrsf18
Available
Manufacturer - Isotype	Rat IgG2b
Shipping Temperature	blue ice or room temperature
Storage Conditions	The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze.
Manufacturer - Research Area	Immunology
Background	The DTA-1 monoclonal antibody specifically reacts with mouse Glucocorticoid-Induced TNFR-related protein, also known as GITR and TNFRSF18, a 66-70 kDa homodimer glycoprotein, detected in the T cells treated with glucocorticoid dexamethasone. GITR is also expressed in naïve mice by CD25+/CD4+/CD8a- thymocytes and on CD25+/CD4+/CD45RB-low splenocytes. Low levels were detected in splenic CD25+/CD4+/CD45RB-low T cells, B cells, dendritic cells and macrophages. A GITR ligand was detected on dendritic cells, macrophages and B cells.The DTA-1 antibody stimulates GITR and abrogates suppression by T regulatory cells (Treg), without affecting their proliferation. DTA-1 administration or the removal of GITR-expressing cells led to organ specific autoimmune disease.
Purification	The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Concentration	Batch dependent
Buffer	Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Clonality	Monoclonal
NCBI Official Name	tumor necrosis factor receptor superfamily, member 18
NCBI Organism	Mus musculus
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 9/4/2025

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