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AMPKa1 (phospho Ser487) Antibody

AMPKa1 (phospho Ser487) Antibody

Item no.	PRS-79-185-0.1mg
Manufacturer	ProSci
Amount	0.1 mg
Category	Oncology Metabolism Cholesterol & Lipid Metabolism Antibodies By Cell Type Hematology Lymphoma Cell Biology Obesity Cell Status Immunohistochemistry Western Blot Immunofluorescence Autophagy Primary Antibodies
Type	Antibody Primary
Format	Liquid
Applications	WB, IF, IHC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Kim JE, et al. (2005) J Proteome Res. 4 (4): 1339-1346. Woods A, et al. (2003) J Biol Chem. 278 (31): 28434-28442.
NCBI	PRKAA1
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	AMPK,AMPKa1,FLK1,VEGFR2,AAPK1,AMPK alpha-1 chain,AMPK-alpha1,HMG-CoA redustase kinase,PRKAA1
Shipping Condition	Cool pack
Available
Manufacturer - Type	Primary Antibodies
Shipping Temperature	Blue Ice
Storage Conditions	Store antibody at -20˚ C for up to one year.
Molecular Weight	63 kDa
Manufacturer - Research Area	Phospho-Specific
Background	Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.
By Type	Phospho-Specific
Modifications	Phospho-Specific
Protein Gi #	94557301
Purification	Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration	1 mg/mL
Buffer	Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Application Note	Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Manufacturer - Specificity	This antibody detects endogenous level of AMPKα 1 only when phosphorylated at serine 487.
Immunogen	AMPKa1 (Phospho-Ser487) antibody was raised in was raised against a peptide sequence around phosphorylation site of serine 487 (S-G- SP-V-S) derived from Human AMPKα 1.
Clonality	Polyclonal
NCBI Official Name	protein kinase, AMP-activated, alpha 1 catalytic subunit
NCBI Organism	Homo sapiens
Disclaimer	Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mg

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Delivery expected until 1/1/2026

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