IKK a (Ab 23) Antibody

blue ice or room temperature

85 kDa

Acts as part of the IKK complex in the conventional pathway of NF-κ -B activation and phosphorylates inhibitors of NF-κ -B thus leading to the dissociation of the inhibitor/NF-κ -B complex and ultimately the degradation of the inhibitor. As part of the non-canonical pathway of NF-κ -B activation, the MAP3K14-activated CHUK/IKKA homodimer phosphorylates NFKB2/p100 associated with RelB, inducing its proteolytic processing to NFKB2/p52 and the formation of NF-κ -B RelB-p52 complexes. Also phosphorylates NCOA3. Phosphorylates 'Ser-10' of histone H3 at NF-κ -B-regulated promoters during inflammatory responses triggered by cytokines.

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Polyclonal

Homo sapiens