TIM-3 ELISA Matched Antibody Pair (Risk Free)

Blue Ice

The immune checkpoint protein TIM3 is a member of the immunoglobulin superfamily and TIM family of proteins that was initially identified as a specific marker of fully differentiated IFN-γ producing CD4 T helper 1 (Th1) and CD8 cytotoxic cells. It is a Th1-specific cell surface protein that regulates macrophage activation and negatively regulates Th1-mediated auto- and alloimmune responses, and is also highly expressed on regulatory T cells, monocytes, macrophages, and dendritic cells (1). TIM3 and PD-1 are co-expressed on most CD4 and CD8 T cells infiltrating solid tumors or in hematologic malignancy in mice; blocking TIM3 in conjugation with a PD-1 blockade increases the functionality of exhausted T cells and synergizes with to inhibit tumor growth (2, 3).

ProSci's Risk-FreeTM antibodies are mouse monoclonal antibodies made to improve in vivo studies. Unlike antibodies developed using proteins made in yeast or bacteria, Risk-FreeTM antibodies are developed with antigens expressed in mammalian cell lines, giving the most native post-translational modifications to the protein.
Validated for flow cytometry and ELISA
Rigorously tested for the following applications:
Immunoblot
Immunohistochemistry
Immunocytochemistry
Immunofluorescence
Multiple antibodies per target allowing the user to choose the best antibody for their application
Available individually or as a set
Risk-FreeTM means they are guaranteed to work for their approved applications

Antibodies are supplied as protein A purified IgG1.

PBS containing 0.02% sodium azide.

Monoclonal

Optimal dilutions for each application to be determined by the researcher.