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p38 MAPK (phospho Thr180 / Tyr182) Antibody

p38 MAPK (phospho Thr180 / Tyr182) Antibody

Item no.	PRS-XPS-1020-0.1mL
Manufacturer	ProSci
Amount	0.1 mL
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Protein Aggregation, Clearance & Misfolding Antibodies By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Western Blot Primary Antibodies Glial Cell Markers
Type	Antibody Primary
Format	Liquid
Applications	WB
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Conjugate/Tag	Unconjugated
Citations	Shi, Y. and Gaestel, M. "In the cellular garden of forking paths: How p38 MAPKs signal for downstream assistance," Biol. Chem. 383 (2002) 1519 - 1536. Johnson, G.L. and Lapadat, R. "Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases," Science 298 (2002) 1911 - 1912. Toska, K., Kleppe, R., Armstrong, C.G., Morrice, N.A., Cohen, P. and Haavik, J. "Regulation of tyrosine hydroxylase by stress-activated protein kinases," J. Neurochem. 83 (2002) 775 -783. Choe, E.S. and McGinty, J.F., "N-methyl-D-aspartate receptors and P38 mitogen-activated protein kinase are required for cAMP-dependent cyclase response element binding protein and ELK-1 phosphorylation in the striatum," Neurosci. 101 (2000) 607 - 617.
NCBI	Mapk14
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Manufacturer - Applications	Immunolabeling in Western blots of C-6 glioma cells prepared with anisomycin treatment is blocked by the phosphopeptide used as antigen but not by the corresponding dephosphopeptide. Applications include Immunoblotting (DB) and Western Blots (WB). Immunohistochemistry (IHC): not yet determined. Human, mouse and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Shipping Temperature	blue ice or room temperature
Storage Conditions	For long term storage –80°C is recommended, but shorter term storage at –20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Molecular Weight	39
Manufacturer - Research Area	Cancer , Signal Transduction , Neuroscience , Phospho-Specific
Background	The three Mitogen-Activated Protein Kinases (MAPKs) are evolutionarily conserved protein kinases that control a vast array of cellular processes. p38 MAPK is one these kinases and it is activated by both inflammatory cytokines and by stress. The p38 MAPK is thought to be particularly important in diseases like asthma and autoimmunity but it also plays important roles in the stress response of the nervous system. Like the other MAPKs, p38 is activated by a dual specificity kinase that phosphorylates Thr180 and Tyr182.
Modifications	Phospho-Specific
Protein Gi #	2499601
Purification	Affinity Purified
Immunogen	p38 MAPK (Thr180/Tyr182) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho Thr180/Tyr182 of p38.
Clonality	Polyclonal
NCBI Official Name	mitogen activated protein kinase 14
NCBI Organism	Rattus norvegicus
Disclaimer	This product is for research use only.
User Note	Optimal dilutions for each application to be determined by the researcher.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 0.1 mL

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