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Anti-Histone H2A.X Mouse mAb

Anti-Histone H2A.X Mouse mAb

Item no.	PTM-1005
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Monoclonal
Format	Lyophilized powder
Applications	WB
Clone	2H8
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Meigui Zhang, et al. (2E)-1-(2,4,6-Trimethoxyphenyl)-3-(4-chlorophenyl)prop-2-en-1-one, a Chalcone Derivative, Promotes Apoptosis by Suppressing RAS-ERK and AKT/FOXO3a Pathways in Hepatocellular Carcinoma Cells. CHEMISTRY & BIODIVERSITY, 2023. https://onlinelibrary.wiley.com/doi/abs/10.1002/cbdv.202300050.
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Alias	Histone H2AX,H2a/x,H2AX,H2AFX
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Category	Histone & Histone Modification Antibodies
Manufacturer - Targets	Histone H2A.X
Shipping Temperature	Ambient temperature
Storage Conditions	Store at -20°C. Avoid freeze/thaw cycles.
Molecular Weight	15
Stability	Stable for 12 months from date of receipt/reconstitution.
Manufacturer - Research Area	Epigenetics
Product description	Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Among core histones, the H2A family shows the highest sequence divergence, especially in the C-terminal region, leading to variants including H2A.Z, H2A.X, MacroH2A, H2A.B etc. H2A histone family member X (H2A.X) is a histone H2A variant encoded by the H2AFX gene. H2A.X contributes to nucleosome-formation, chromatin-remodeling and DNA double-strand break repair and is considered as a tumor suppressor. An early cellular response to DNA damage is the rapid phosphorylation of H2A.X at position Ser139.
Purification Method	Protein G and immunogen affinity purified
Manufacturer - Specificity	Anti-Histone H2A.X Mouse mAb detects endogenous levels of histone H2A.X protein. It does not cross-react with other histone or non-histone proteins.
Formula	PBS, Glycerol, BSA
PTM	Unmodified
Immunogen	Synthetic peptide corresponding to the C-terminus of human histone H2A.X protein
Clonality	Monoclonal
Background	Histones are a family of basic proteins that form the core of the nucleosome – the fundamental structural unit of chromatin. In a single nucleosome, core histone proteins H2A, H2B, H3, and H4 form an octamer around which the DNA is tightly wrapped. Among core histones, the H2A family shows the highest sequence divergence, especially in the C-terminal region, leading to variants including H2A.Z, H2A.X, MacroH2A, H2A.B etc. H2A histone family member X (H2A.X) is a histone H2A variant encoded by the H2AFX gene. H2A.X contributes to nucleosome-formation, chromatin-remodeling and DNA double-strand break repair and is considered as a tumor suppressor. An early cellular response to DNA damage is the rapid phosphorylation of H2A.X at position Ser139.
Cellular Localization	Nucleus

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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Delivery expected until 2/19/2026

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