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Anti-Butyryl-Histone H3 (Lys18) Rabbit pAb

Anti-Butyryl-Histone H3 (Lys18) Rabbit pAb

Item no.	PTM-306
Manufacturer	PTM Biolabs
Amount	100 ul
Category	Antibodies Primary Antibodies
Type	Antibody Polyclonal
Format	Lyophilized powder
Applications	WB, ICC
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Conjugate/Tag	Unconjugated
Citations	Fellows Rachel, et al. Microbiota derived short chain fatty acids promote histone crotonylation in the colon through histone deacetylases. Nature Communications, 2018. https://www.nature.com/articles/s41467-017-02651-5.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Alias	H3K18bu
Shipping Condition	Room temperature
Available
Manufacturer - Type	Primary Antibodies
Manufacturer - Applications	WB, ICC/IF
Manufacturer - Category	Histone & Histone Modification Antibodies
Manufacturer - Targets	Histone H3
Shipping Temperature	Ambient temperature
Storage Conditions	-20°C
Molecular Weight	15
Product description	Histones are subject to a variety of enzyme catalyzed modifications, including acetylation, methylation, phosphorylation, ubiquitylation, etc. Butyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. Lysine butyrylation is highly conserved in eukaryotic cells from worm to human. The unique structure and genomic localization of histone lysine butyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation. Specifically, in both human somatic and rabbit male germ cell genomes, histone butyrylation marks either active promoters or potential enhancers. Butyrylation of histone H3 at Lys18 may play a vital role in the epigenetic modulation, including chromatin remodeling and DNA transcriptional regulation
Purification Method	Protein A and immunogen affinity purified
Manufacturer - Specificity	Anti-Butyryl-Histone H3 (Lys18) Rabbit pAb detects histone H3 only when it is butyrylated at Lys18.
Formula	PBS, Glycerol, BSA
Clonality	Polyclonal

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100 ul

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