Anti-2-Hydroxyisobutyryllysine Mouse mAb

Primary Antibodies

Ambient temperature

Multiple

Post-Translational Modificaiton

Histones are subjected to a variety of enzyme catalyzed modifications, including acetylation, methylation, ubiquitylation, etc. 2-Hydroxyisobutyrylation of lysine is a newly identified reversible modification controlling chromosome structure and gene transcription. The reversible lysine 2-hydroxyisobutyrylation has been well demonstrated in eukaryotic histones from worm to human. The unique structure and genomic localization of histone lysine 2-hydroxyisobutyrylation suggest that it is mechanistically and functionally different from histone lysine acetylation.

Anti-2-Hydroxyisobuyrylated Mouse mAb detects proteins with 2-hydroxyisobutyrylated lysine residues. This pan antibody recognizes 2-hydroxyisobutyrylated lysine independent of its surrounding sequences.

2-Hydroxyisobutyryl

Monoclonal