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Anti-Human CD62L (L-Selectin) SAFIRE Purified 50 ug

Anti-Human CD62L (L-Selectin) SAFIRE Purified 50 ug

Item no.	04731-25-50
Manufacturer	BioGems
Amount	50 ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Neural Adhesion Molecules Antibodies Cell Biology Cell Movement Cell Adhesion Flow Cytometry Primary Antibodies By Organ Heart & Blood Cancer
Type	Antibody
Format	SAFIRE Purified
Applications	FC
Clone	DREG-56
Specific against	Human (Homo sapiens)
Host	Rat
Isotype	IgG2a Kappa
Citations	Gallatin, W. M., Weissman, I. L., & Butcher, E. C. (1982). A cell-surface molecule involved in organ-specific homing of lymphocytes. Nature, 304(5921), 30-34. Siegelman, M. H., Cheng, I. C., Weissman, I. L., & Wakeland, E. K. (1990). The mouse lymph node homing receptor is identical with the lymphocyte cell surface marker Ly-22: role of the EGF domain in endothelial binding. Cell, 61(4), 611-622. Pizcueta, P., & Luscinskas, F. W. (1994). Monoclonal antibody blockade of L-selectin inhibits mononuclear leukocyte recruitment to inflammatory sites in vivo. The American journal of pathology, 145(2), 461.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The MEL-14 monoclonal antibody specifically reacts with L- selectin (CD62L), a receptor with lectin-like and Epidermal Growth Factor-like domains. The weight of the CD62L molecules depend on their origin, 74 kDa on lymphocytes or 95 kDa on neutrophils. In the mouse organism, CD62L can be expressed by most thymocytes, on subsets of B and T lymphocytes, monocytes, eosinophils, and neutrophils. The L-selectin binds sulfated, fucosylated, and glycosylated glycoproteins (MadCAM-1, GLYCAM-1, and CD 34). It mediates the migration of lymphocytes to the site of inflammation and their return to the peripheral lymphoid tissues and to the HEV (high endothelial venules). In vitro, L-selectin inhibits this binding and the lymphocyte extravasation into peripheral lymph nodes. After cell activation, it is quickly shed by neutrophils and lymphocytes.
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Adaptive Immunity, Angiogenesis
Format	SAFIRE Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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04731-25-50-datasheet.pdf

04731-25-50-safety-datasheet.pdf