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Anti-Human CD28 Purified

Anti-Human CD28 Purified

Item no.	10311-20-100
Manufacturer	BioGems
Amount	100 ug
Category	Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies
Type	Antibody
Format	Purified
Applications	FC, IP, IHC
Clone	CD28.2
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG1 Kappa
Citations	Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York Nunas, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., ... & Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology, 5(3), 311-315. Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., & Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load. Journal of virology, 81(24), 13444-13455.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Adaptive Immunity
Format	Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

10311-20-100-datasheet.pdf

10311-20-100-safety-datasheet.pdf