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Anti-Human CD184 (CXCR4) Purified 25 ug

Anti-Human CD184 (CXCR4) Purified 25 ug

Item no.	16911-20-25
Manufacturer	BioGems
Amount	25 ug
Category	Oncology Neuroscience Neural Lineage Markers Neuroinflammation Molecular Targets for Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Leukemia Lymphoma Flow Cytometry Cardiovascular Research Atherosclerosis Primary Antibodies
Type	Antibody
Format	Purified
Applications	FC
Clone	12G5
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2a Kappa
Citations	Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., & Mackay, C. R. (1997). The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proceedings of the National Academy of Sciences,94(5), 1925-1930. Feng, Y., Broder, C. C., Kennedy, P. E., & Berger, E. A. (1996). HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science, 272(5263), 872-877. Simmons, G., Wilkinson, D., Reeves, J. D., Dittmar, M. T., Beddows, S., Weber, J., ... & Clapham, P. R. (1996). Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. Journal of Virology, 70(12), 8355-8360.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The 12G5 monoclonal antibody specifically bind to human CD184 (CXCR4), a seven-transmembrane G-protein-coupled receptor. It is widely expressed on endothelial cells, hematopietic cells, and also on naive T cell subsets. CD184 is the receptor for SDF-1 and an alternative receptor for HIV-1. The 12G5 antibody is reported to inhibit SDF-1 induced chemotaxis and calcium influx and some CD4-dependent infections of HIV-1.
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.
Research Interest	Angiogenesis, Stem Cell Research
Format	Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

16911-20-25-datasheet.pdf

16911-20-25-safety-datasheet.pdf