Anti-Human CD127 (IL-7Ra) APC

The R34-34 monoclonal antibody specifically reacts with the human interleukin-7 receptor α chain (IL-7 Ra, also known as CD127), which interacts with the γ chain (CD132) and forms the heterodimer known as IL-7 receptor complex. The IL-7 receptor plays a very important role in signal transduction, in the development of lymphocytes, and in the control of T lymphocytes peripheral proliferation. CD 127 is a 60-90 kDa glycoprotein expressed on the surface of thymocytes, mature T lymphocytes, B and T lymphocytes progenitors, some myeloid cells, and some lymphoid cells. Recent studies have shown that in vitro down-regulation of CD127 expression in CD4-positive/CD25-positive regulatory T cells increases the enrichment of regulatory T cells of transcription factor Foxp3 and suppressive activity.

The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.