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Anti-Human CD279 (PD-1) SAFIRE Purified

Anti-Human CD279 (PD-1) SAFIRE Purified

Item no.	31821-25-25
Manufacturer	BioGems
Amount	25 ug
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies By Cell Type Carcinoma Hematology Lymphoma Myelofibrosis Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies
Type	Antibody
Format	SAFIRE (Functional)
Applications	FC, IP, IHC
Clone	J116
Specific against	Human (Homo sapiens)
Host	Hamster - Armenian
Isotype	IgG
Citations	Nishimura, H., Agata, Y., Kawasaki, A., Sato, M., Imamura, S., Minato, N., ... & Honjo, T. (1996). Developmentally regulated expression of the PD-1 protein on the surface of double-negative (CD4-"CD8-") thymocytes. International immunology, 8(5), 773-780. Salama, A. D., Chitnis, T., Imitola, J., Ansari, M. J. I., Akiba, H., Tushima, F., ... & Khoury, S. J. (2003). Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. The Journal of experimental medicine, 198(1), 71-78. Carreno, B. M., & Collins, M. (2002). The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annual review of immunology, 20(1), 29-53.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The J116 monoclonal antibody specifically reacts with human Programmed death-1 (PD-1 or CD279), a 50-55 kDA glycoprotein. It is expressed on mainly on activated B, T, and myeloid cells. Within the cytoplasmic region, PD-1 contains an Immunoreceptor tyrosine-based inhibitory motif (ITIM) and seems to regulate peripheral tolerance. The lack or mutation of CD279 is linked to autoimmune disorders.The J116 antibody does not block the binding of the PD-1 ligand, but does inhibit the PD-1 signal transduction.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ph7.2.
Preperation	The product should be stored undiluted at 4C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µ g of the protein.
Research Interest	Adaptive Immunity, Apoptosis
Format	SAFIRE (Functional)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

31821-25-25-datasheet.pdf

31821-25-25-safety-datasheet.pdf