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Anti-Human Fc epsilon Receptor I alpha (FceR1) FITC 100 tests

Anti-Human Fc epsilon Receptor I alpha (FceR1) FITC 100 tests

Item no.	84111-50-100
Manufacturer	BioGems
Amount	100 tests
Category	Food Safety Histamines Antibodies Flow Cytometry Primary Antibodies
Type	Antibody
Format	FITC
Applications	FC
Clone	AER-37 (CRA1)
Specific against	Human (Homo sapiens)
Host	Mouse
Isotype	IgG2b Kappa
Conjugate/Tag	FITC
Citations	Maurer, D., Fiebiger, E., Ebner, C., Reininger, B., Fischer, G. F., Wichlas, S., ... & Stingl, G. (1996). Peripheral blood dendritic cells express FceRI as a complex composed of FceRIa-and FceRIy-chains and can use this receptor for IgE-mediated allergen presentation. J Immunol, 157, 607-616. Yamaguchi, M., Sayama, K., Yano, K., Lantz, C. S., Noben-Trauth, N., Ra, C., ... & Galli, S. J. (1999). IgE enhances Fcε receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fcε receptor I expression and mediator release. The Journal of Immunology,162(9), 5455-5465. Ra, C., Kuromitsu, S., Hirose, T., Yasuda, S., Furuichi, K., & Okumura, K. (1993). Soluble human high-affinity receptor for IgE abrogates the IgE-mediated allergic reaction. International immunology, 5(1), 47-54.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The AER-37 (CRA1) antibody binds to the FC epsilon receptor I alpha subunit (FceR1a), a 50 kDA transmembrane protein. It is part of a tetrameric receptor complex composed from one alpha subunit, one beta subunit, and two gamma subunits. The FceR1a binds and is upregulated by the presence of IgE. It plays a role in prompting the allergic reactions mediated by IgE.
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Innate Immunity

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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84111-50-100-datasheet.pdf

84111-50-100-safety-datasheet.pdf