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Anti-Human/Mouse CD44 APC

Anti-Human/Mouse CD44 APC

Item no.	06511-80-25
Manufacturer	BioGems
Amount	25 ug
Category	Oncology Neuroscience Aging & Neurological Disorders Antibodies Flow Cytometry Primary Antibodies By Organ Gastric Cancer
Type	Antibody
Format	APC
Applications	FC
Clone	IM7
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG2b Kappa
Conjugate/Tag	APC
Citations	Trowbridge, I. S., Lesley, J., Schulte, R., Hyman, R., & Trotter, J. (1982). Biochemical characterization and cellular distribution of a polymorphic, murine cell-surface glycoprotein expressed on lymphoid tissues. Immunogenetics,15(3), 299-312. Lesley, J., & Trowbridge, I. S. (1982). Genetic characterization of a polymorphic murine cell-surface glycoprotein. Immunogenetics, 15(3), 313-320. Nedvetzki, S., Walmsley, M., Alpert, E., Williams, R. O., Feldmann, M., & Naor, D. (1999). CD44 involvement in experimental collagen-induced arthritis (CIA). Journal of autoimmunity, 13(1), 39-47.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The IM7 monoclonal antibody specifically reacts with all the isoforms and both alloantigens of the CD44 glycoprotein (Pgp-1, Ly-24). CD44 is expressed on hematopoietic and non-hematopoietic cells, bone marrow myeloid cells, memory T lymphocytes, periphery activated B cells, CD4+ T lymphocytes, and CD8+ T lymphocytes. The periphery B and T lymphocytes upregulate the expression of CD44. CD44 binds to hyaluronan molecules, acting as an adhesion molecule. The IM7 antibody inhibits collagen-induced arthritis in DBA/1 mice, prevents central nervous system inflammation associated with experimental autoimmune encephalomyelitis, but exacerbates the experimental autoimmune thyroiditis in CBA/J mice. The IM7 antibody also cross-reacts with dog, human, pig, horse, cat, and cow leukocytes.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Adaptive Immunity, Angiogenesis, Stem Cell Research

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

06511-80-25-datasheet.pdf

06511-80-25-safety-datasheet.pdf