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Anti-Mouse CD25 Purified

Anti-Mouse CD25 Purified

Item no.	07312-20-100
Manufacturer	BioGems
Amount	100 ug
Category	Oncology Neuroscience Neural Lineage Markers Aging & Neurological Disorders Antibodies By Cell Type Hematology Leukemia Lymphoma Flow Cytometry Immunohistochemistry Immunoprecipitation Primary Antibodies
Type	Antibody
Format	Purified
Applications	FC, IP, IHC
Clone	PC61.5
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG1 Lambda
Citations	Hayashi, T., Hasegawa, K., & Adachi, C. (2005). Elimination of CD4+ CD25+ T cell accelerates the development of glomerulonephritis during the preactive phase in autoimmune-prone female NZBA— NZW F1 mice. International journal of experimental pathology, 86(5), 289-296. Lowenthal, J. W., Tougne, C., MacDonald, H. R., Smith, K. A., & Nabholz, M. (1985). Antigenic stimulation regulates the expression of IL 2 receptors in a cytolytic T lymphocyte clone. The Journal of Immunology, 134(2), 931-939. Huang, B., Zhao, J., Shen, S., Li, H., He, K. L., Shen, G. X., ... & Feng, Z. H. (2007). Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Research, 67(9), 4346-4352.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The PC61.5 antibody specifically reacts with mouse CD25, the 55 kDa low-affinity Interleukin-2 Receptor α chain (IL-2R α), expressed on early progenitors of T and B lineage, and on B and T cells. Together with CD122 (IL-2 Receptor β) and CD 132 (IL-2 Receptor γc, the common gamma chain), CD25 forms high-affinity receptor complexes for IL-2. Resting B and T cells and natural killer cells do not express IL-2Rα. Cd25 is also expressed on the dendritic cells, and it enhances lymphocyte differentiation and activation. The PC61.5 antibody blocks the binding of IL-2 to both high-affinity and low-affinity receptors.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Adaptive Immunity
Format	Purified

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

07312-20-100-datasheet.pdf

07312-20-100-safety-datasheet.pdf