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Anti-Mouse KLRG1 BG Violet 450

Anti-Mouse KLRG1 BG Violet 450

Item no.	82112-40-100
Manufacturer	BioGems
Amount	100 ug
Category	Oncology Antibodies Flow Cytometry Primary Antibodies By Organ Bone Cancer
Type	Antibody
Format	BG Violet 450
Applications	FC
Clone	2F1
Specific against	Mouse (Murine, Mus musculus)
Host	Hamster - Armenian
Isotype	IgG
Conjugate/Tag	BG Violet 450
Citations	Beyersdorf, N. B., Ding, X., Karp, K., & Hanke, T. (2001). Expression of inhibitory" killer cell lectin-like receptor G1" identifies unique subpopulations of effector and memory CD8 T cells. European journal of immunology, 31(12), 3443-3452. Corral, L., Hanke, T., Vance, R. E., Cado, D., & Raulet, D. H. (2000). NK cell expression of the killer cell lectin-like receptor G1 (KLRG1), the mouse homolog of MAFA, is modulated by MHC class I molecules. European journal of immunology, 30(3), 920-930. Robbins, S. H., Terrizzi, S. C., Sydora, B. C., Mikayama, T., & Brossay, L. (2003). Differential regulation of killer cell lectin-like receptor G1 expression on T cells. The Journal of Immunology, 170(12), 5876-5885.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The 2F1 monoclonal antibody is specific for the mouse Killer cell Lectin-like Receptor G1 (KLRG1), a homodimer consisting of two N-glycosylated subunits of 30-38 kDa, also known as MAFA (Mast cell Function-associated Antigen). The antigen contains a cytoplasmic motif similar to ITIM (the immunoreceptor tyrosine-based inhibitory motif). KLRG1 is a receptor for cadherin, a family of transmembrane glycoproteins that mediate cell adhesion, and a common marker of T cell senescence. The receptor is believed to play an important role in the innate and adaptive immune system through the regulation of leukocytes. It is expressed on lymphokine-activated killer (LAK) cells, adherent LAK (A-LAK) cells, a sub-set of natural killer (NK) cells, T cells. In NK cells, it inhibits cytokine production and cytotoxicity activity. The receptor expression was not detected on the mouse peritoneal mast cells, or bone marrow mast cells.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Innate Immunity, Adaptive Immunity
Manufacturers conjugate	BG Violet 450

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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82112-40-100-datasheet.pdf

82112-40-100-safety-datasheet.pdf