Anti-Mouse TNF-Alpha APC

Item no.	84422-80-100
Manufacturer	BioGems
Amount	100 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Flow Cytometry Primary Antibodies
Type	Antibody
Format	APC
Applications	FC
Clone	MP6-XT22
Specific against	Mouse (Murine, Mus musculus)
Host	Rat
Isotype	IgG1 Kappa
Conjugate/Tag	APC
Citations	Abrams, J. S. (1995). Immunoenzymetric assay of mouse and human cytokines using NIP-labeled anti-cytokine antibodies. Current Protocols in Immunology, 6-20. Williams, R. O., Mauri, C., Mason, L. J., Marinova-Mutafchieva, L., Ross, S. E., Feldmann, M., & Maini, R. N. (1998). Therapeutic actions of cyclosporine and anti-tumor necrosis factor α in collagen-induced arthritis and the effect of combination therapy. Arthritis & Rheumatism, 41(10), 1806-1812. Litton, M. J., Remington, J. S., & Abrams, J. S. (1994). Immunocytochemical detection of cytokines in the lymph nodes and brains of mice resistant or susceptible to toxoplasmic encephalitis. Journal of Infectious Diseases, 170(4), 939-945.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The MP6-XT22 monoclonal antibody specifically reacts with mouse tumor necrosis factor alpha (TNF-alpha), a 156 amino pro-inflammatory cytokine. It is secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. NF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes. The MP6-XT22 is reported to neutralize the bioactivity of natural or recombinant TNF-alpha and is useful for intracellular immunofluorescent staining.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Innate Immunity, Apoptosis

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84422-80-100-datasheet.pdf

84422-80-100-safety-datasheet.pdf