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Anti-Mouse/Rat TNF-alpha SAFIRE Purified

Anti-Mouse/Rat TNF-alpha SAFIRE Purified

Item no.	84412-25-500
Manufacturer	BioGems
Amount	500 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Antibodies By Cell Type Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis Flow Cytometry Primary Antibodies
Type	Antibody
Format	SAFIRE (Functional)
Applications	FC
Clone	TN3-19
Specific against	Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Mouse
Isotype	IgG
Citations	Danis, V. A., Franic, G. M., Rathjen, D. A., & Brooks, P. M. (1991). Effects of granulocyte-macrophage colony-stimulating factor (GM-CSF), IL-2, interferon-gamma (IFN-γ), tumour necrosis factor-alpha (TNF-α) and IL-6 on the production of immunoreactive IL-1 and TNF-α by human monocytes. Clinical & Experimental Immunology, 85(1), 143-150. Prussin, C., & Metcalfe, D. D. (1995). Detection of intracytoplasmic cytokine using flow cytometry and directly conjugated anti-cytokine antibodies. Journal of immunological methods, 188(1), 117-128. Andersen, H., Rossio, J. L., Coalter, V., Poore, B., Martin, M. P., Carrington, M., & Lifson, J. D. (2004). Characterization of rhesus macaque natural killer activity against a rhesus-derived target cell line at the single-cell level. Cellular immunology, 231(1), 85-95.
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Description	The TN3-19 monoclonal antibody reacts with mouse and rat tumor-necrosis (TNF) alpha proteins. It is not cross-reactive with mouse TNF-Beta or human TNF. TNF-Alpha is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. The TN3-19 antibody is reported to be a neutralizing antibody.
Storage Temperature	4C
Formulation	Phosphate-buffered aqueous solution, ≤ 0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.
Preperation	The product should be stored undiluted at 4C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.
Research Interest	Innate Immunity, Apoptosis, Cytokines & Growth Factors
Format	SAFIRE (Functional)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

84412-25-500-datasheet.pdf

84412-25-500-safety-datasheet.pdf