Mouse monoclonal antibody to human p75NTR [ME20.4] - FITC

Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) due to its molecular mass and its ability to bind at low affinity not only NGF (see 162030), but also other neurotrophins, including brain-derived neurotrophic factor (BDNF, 113505), neurotrophin-3 (NTF3, 162660), and neurotrophin-4/5 (NTF5, 162662). At the time of its discovery, NGFR was considered a unique type of protein. Subsequently, however, a large superfamily of tumor necrosis factor receptors were found to share the overall structure of NGFR (4 extracellular ligand-binding, cysteine-rich repeats, or CRs, and signaling through association with, or disassociation from, cytoplasmic interactors). The identification of this superfamily helped elucidate some of the biologic functions of NGFR, including its ultimate involvement in the nuclear factor kappa-B (NFKB, see 164011) and apoptosis pathways. As a monomer, NGFR binds NGF with low affinity. Higher affinity binding is achieved by association with higher molecular mass, low-affinity neurotrophin receptors, namely the tropomyosin receptor kinases, TRKA (NTRK1, 191315), TRKB (NTRK2, 600456), and TRKC (NTRK3, 191316). TRKA, TRKB, and TRKC are specific for or 'preferred by' NGF, NTF5 and BDNF, and NTF3, respectively. NTF3 also binds to TRKA and TRKB, but with significantly lower affinity.

The antibody conjugate can be stored at 4AC for up to 4 months with the addition of appropriate antibacterial agent.

Liquid. 10mM Tris, 50mM NaCl

Reacts with human, cat, dog, pig, rabbit and sheep. Does not react with rat or mouse.

This antibody recognises p75NTR (low affinity neurotrophin receptor)