Rabbit antibody to human CDNF (conserved dopamine neurotrophic factor)

CDNF (conserved dopamine neurotrophic factor) is a trophic factor for midbrain dopamine neurons in vivo. It prevents the 6-OHDA- (Lindholm et al. 20007, Voutilainen et al., 2011) and MPTP-induced degeneration (Airavaara et al., 2012) of dopamine neurons in rodent models of Parkinsona€s disease. When administered after 6-OHDA or MPTP a€“lesioning it restores the dopaminergic function and prevents degeneration of dopamine neurons in substantia nigra pars compacta.

Store at +4AC upon receipt, Do not freeze. See reconstitution instructions for handling information.

Concentrated ammonium sulphate in PBS pH 7.4 containing no preservatives.

Rabbit

Store antibody stock solution at +4AC upon receipt. DO NOT FREEZE. This product is an (NH4)2SO4 precipitate. To use, mix well by pipetting or vortexing gently prior use, then withdraw the desired amount of antibody stock solution and dilute into your antibody dilution buffer and use normally.
Alternatively, material can be centrifuged at 10K x g for 5 minutes and the liquid sulfate solution carefully removed. Then precipitated antibody can be resuspended in 0.1M P, 250mM NaCL, pH 7.4 solution. The solution should then be divided into working aliquots and stored at -80AC until used. Prevent multiple freeze thaw cycles of aliquots for best product life.