Rabbit antibody to human Synapsin (Phosphos-Ser9)

Synapsin is a neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is thought to function in the regulation of neurotransmitter release. Synapsin exists as a homodimer and at the subcellular level is located at the cell junction and synapse. It interacts with CAPON and forms a ternary complex with NOS1. Synapsin is a substrate of at least four different protein kinases and it is likely that phosphorylation plays a role in its regulation in the nerve terminal. Defects in SYN1 cause X-linked recessive epilepsy associated with variable learning disabilities and behaviour disorders.

It is recommended that a thawed sample is stored at 4C for no longer than 2 weeks. Allocation of appropriate anti-bacterial agent can increase shelf life by several weeks. Diluted serum should be prepared as required. Long term stability requires storage, preferably in small aliquots at -20C or lower.

Lyophilised

This antibody is known to cross-react with mouse and rat synapsin. Other species have not yet been tested.

Synapsin (phospho-Ser9) antibody detects endogenous levels of synapsin only when phosphorylated at serine 9.