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Mouse monoclonal antibody to Neurofilament Heavy, phosphorylated [NAP4]

Mouse monoclonal antibody to Neurofilament Heavy, phosphorylated [NAP4]

Item no.	M-1387-50
Manufacturer	Biosensis
Amount	50ul
Category	Neuroscience Neural Lineage Markers Metabolism Glucose Homeostasis Molecular Targets for Neuroscience Antibodies Western Blot Immunocytochemistry Primary Antibodies Neurodegeneration Markers Glial Cell Markers
Type	Antibody Monoclonal
Applications	WB, ICC
Clone	NAP4
Specific against	other
Host	Mouse
Isotype	IgG1
ECLASS 10.1	42030590
ECLASS 11.0	42030590
UNSPSC	12352203
Similar products	NF-H, NEFH, NF-200, NF200, N52, Neurofilament heavy polypeptide, Neurofilament triplet H protein, 200 kDa neurofilament protein, KIAA0845, NFH
Available
Sub category	Development-Cell Markers
products_extra_fields_value	Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
products_quantity	200
storage	After reconstitution of lyophilised antibody, aliquot and store at -20AC for a higher stability. Avoid freeze-thaw cycles.
formulation	Lyophilised with 5% trehalose
immunogen	Full length native protein (purified) from Pig spinal cord.
crossreactivity	Chicken, Rat. Predicted to react with mammals due to sequence homology.
conality	Mouse
specificity	The specificity of this antibody has been confirmed by WB. This antibody recognises phosphorylated NF-H KSP (lysine-serine-proline) type sequences. In some species there is some cross-reactivity with the related KSP sequences found in subunit NF-M.
reconstitution	Reconstitute in sterile distilled water. Centrifuge to remove any insoluble material.
specificreferences	1. Boylan K. et al (2009) Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker. J Neurochem. 2009 Dec, 111(5):1182-91. 2. Rangaraju S. et al (2009) Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell. 2009 Apr, 8(2):178-91.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50ul

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Delivery expected until 12/18/2025

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