Comparison

Mouse monoclonal antibody to Neurofilament Heavy, phosphorylated [NAP4]

Item no. M-1387-50
Manufacturer Biosensis
Amount 50ul
Category
Type Antibody Monoclonal
Applications WB, ICC
Clone NAP4
Specific against other
Host Mouse
Isotype IgG1
ECLASS 10.1 42030590
ECLASS 11.0 42030590
UNSPSC 12352203
Similar products NF-H, NEFH, NF-200, NF200, N52, Neurofilament heavy polypeptide, Neurofilament triplet H protein, 200 kDa neurofilament protein, KIAA0845, NFH
Available
Sub category
Development-Cell Markers
products_extra_fields_value
Neurofilaments contain three intermediate filament proteins: light (68 kDa), medium (160 kDa) and heavy (200 kDa). Neurofilament heavy (NF200 or NF-H) is phosphorylated and it is thought that this results in the formation of interfilament cross bridges that are important in the maintenance of axonal caliber.
products_quantity
200
storage
After reconstitution of lyophilised antibody, aliquot and store at -20AC for a higher stability. Avoid freeze-thaw cycles.
formulation
Lyophilised with 5% trehalose
immunogen
Full length native protein (purified) from Pig spinal cord.
crossreactivity
Chicken, Rat. Predicted to react with mammals due to sequence homology.
conality
Mouse
specificity
The specificity of this antibody has been confirmed by WB. This antibody recognises phosphorylated NF-H KSP (lysine-serine-proline) type sequences. In some species there is some cross-reactivity with the related KSP sequences found in subunit NF-M.
reconstitution
Reconstitute in sterile distilled water. Centrifuge to remove any insoluble material.
specificreferences
1. Boylan K. et al (2009) Immunoreactivity of the phosphorylated axonal neurofilament H subunit (pNF-H) in blood of ALS model rodents and ALS patients: evaluation of blood pNF-H as a potential ALS biomarker. J Neurochem. 2009 Dec, 111(5):1182-91.
2. Rangaraju S. et al (2009) Molecular architecture of myelinated peripheral nerves is supported by calorie restriction with aging. Aging Cell. 2009 Apr, 8(2):178-91.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 50ul
Available: In stock
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