Rabbit antibody to ChAT (167-188): whole serum

This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer's disease. Polymorphisms in this gene have been associated with Alzheimer's disease and mild cognitive impairment. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq, May 2010]

After reconstitution keep aliquots at -20AC for a higher stability, and at 4AC with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

Lyophilised

This antiserum is known to react with ChAT of origin guinea-pig, mouse, rat and rabbit.

This antiserum stains cholinergic neurons in guinea-pig and rabbit.

1. Li S et al (2011) The expression and localization of Prune2 mRNA in the central nervous system. Neurosci Lett. 2011 Oct 10, 503(3):208-14.