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Rabbit polyclonal to Lamin A/C

Rabbit polyclonal to Lamin A/C

Item no.	R-1697-100
Manufacturer	Biosensis
Amount	100uL
Category	Oncology Neuroscience Neural Lineage Markers Antibodies By Cell Type Carcinoma Sarcoma Cell Biology Cytoskeleton Western Blot Immunocytochemistry Primary Antibodies Intermediate filaments By Organ Breast Cancer
Type	Antibody Polyclonal
Applications	WB, ICC
Specific against	other
Host	Rabbit
ECLASS 10.1	32160702
ECLASS 11.0	32160702
UNSPSC	12352203
Available
Sub category	Apoptosis
products_extra_fields_value	The Lamin proteins are members of the intermediate filament protein family but are located inside the nucleus rather than in the cytoplasm (1). The lamins function as skeletal components tightly associated with the inner nuclear membrane. Originally the proteins of the nuclear cytoskeleton were named Lamin A, B and C, from top to bottom as visualized on SDS-PAGE gels. Subsequently it was found that Lamins A and C were coded for by a single gene (2), while the Lamin B band may contain two proteins encoded by two genes now called Lamin B1 and Lamin B2. Lamin A has a mass of about 74kDa while Lamin C is 65kDa. The Lamin A protein includes 98 amino acids missing from Lamin C, while Lamin C has a C-terminal 6 amino acid peptide not present in Lamin A. Apart from these regions Lamin A and C are identical so that antibodies raised against either protein are likely to cross react with the other, as is the case with this monoclonal. Lamin polymerization and depolymerization is regulated by phosphorylation by cyclin dependent protein kinase 1 (CDK1), the key component of "maturation promoting factor", the central regulator of cell division. Activity of this kinase increases during cell division and is responsible for the breakdown of the nuclear lamina. Mutations in the LMNA gene are associated with several serious human diseases, including Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease type 2B1, and Hutchinson-Gilford progeria syndrome. This family of diseases belong to a larger group which are often referred to as Laminopathies, though some laminopathies are associated in defects in Lamin B1, B2 or one or other of the numerous nuclear lamina binding proteins. A truncated version of lamin A, commonly known as progerin, causes Hutchinson-Gilford progeria syndrome, a form of premature aging (3).
products_quantity	200
storage	After reconstitution of lyophilized antibody, aliquot and store at -20AC for a higher stability. Avoid freeze-thaw cycles.
formulation	Lyophilized from PBS. Contains 0.5% sodium azide.
immunogen	Full length recombinant human Lamin C
conality	Rabbit
specificity	Lamin A and Lamin C. The antibody reacts with a 74kDa and 65kDa band by Western blot on HeLa cell extract. It has also been used successfully for immunocytochemistry on HeLa cell cultures.
reconstitution	Reconstitute in sterile distilled water. Centrifuge to remove any insoluble material.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 100uL

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Delivery expected until 11/13/2025

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