Human Noggin protein expressed in mammalian cells

Noggin is a glycoprotein predominantly expressed by the dorsal mesoderm during embryogenesis and is secreted as a covalently linked homodimer. Noggin is essential for cartilage morphogenesis and joint formation. It is an inhibitor of bone morphogenic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. Defects in Noggin are a cause of symphalangism proximal syndrome (SYM1), ofA multiple synostoses syndrome 1 (SYNS1), of the tarsal-carpal coalition syndrome (TCC), of stapes ankylosis with broad thumb and toes, and of brachydactyly type B2 (BDB2).

Lyophilized products should be stored at 2-8AC. Following reconstitution, short-term storage at 4AC is recommended and longer-term storage of aliquots at -18 to -20AC. Repeated freeze thawing is not recommended.

The Noggin product consists of 5-25% carbohydrate by weight.

It is recommended that 0.5 ml of sterile phosphate-buffered saline be added to the vial.