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MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, His-tagged

MMP 14 (MT1-MMP) prodomain, catalytic domain, and hemopexin domain, His-tagged

Item no.	BTZ-30100123
Manufacturer	BioTeZ
Amount	200 ug/1 ml
Category	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Conjugate/Tag	His
Protein Family	Matrix Metalloproteinases, matrixins
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Purity	> 80 %
Product Subcategory	EC 3.4.24.80
Pathway and Disease	Diseases associated with MMP14 include Winchester Syndrome and Multicentric Osteolysis, Nodulosis, And Arthropathy. Among its related pathways are Signaling events mediated by focal adhesion kinase and Adhesion
Description	MMP14 seems to specifically activate progelatinase A. May thus trigger invasion by tumor cells by activating progelatinase A on the tumor cell surface. May be involved in actin cytoskeleton reorganization by cleaving PTK7. Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2.
Applications Info	Investigation of MT1-MMP, Generation of active MT1-MMP for progelatinase A activation, Degradation of extracellular Matrix, Screening and evaluation of MMP inhibitors, Antigen standard
Alternate Names	Membrane-Type-1 Matrix Metalloproteinase
Sequence	SLGSAQSSSFSPEAWLQQYGYLPPGDLRTHTQRSP QSLSAAIAAMQKFYGLQVTGKADADTMKAMRRPRC GVPDKFGAEIKANVRRKRYAIQGLKWQHNEITFCI QNYTPKVGEYATYEAIRKAFRVWESATPLRFREVP YAYIREGHEKQADIMIFFAEGFHGDSTPFDGEGGF LAHAYFPGPNIGGDTHFDSAEPWTVRNEDLNGNDI FLVAVHELGHALGLEHSSDPSAIMAPFYQWMDTEN FVLPDDDRRGIQQLYGGESGFPTKMPPQPRTTSRP SVPDKPKNPTYGPNICDGNFDTVAMLRGEMFVFKE RWFWRVRNNQVMDGYPMPIGQFWRGLPASINTAYE RKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGR GLPTDKIDAALFWMPNGKTYFFRGNKYYRFNEELR AVDSEYPKNIKVWEGIPESPRGSFMGSDEVFTYFY KGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGGR PDEGTEEETEVTHHHHHH
Accession No	P50281
Composition	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2.
Storage	Store at -70C
Target Modification	No
Expression System	E.coli
Product Subtype	protein fragment
Active?	No
Tag	His-tagged
Gene ID	4323
Molecular Weight	58 kDa
Shipping Temp Min	dry ice
Product description long	Recombinant soluble pro-MT1-MMP is produced as a periplasmic protein in E. coli. The protein contains prodomain, catalytic domain and hemopexin domain of MT1-MMP
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	MMP14

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ug/1 ml

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Delivery expected until 10/30/2025

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