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MMP 16 (MT3-MMP) catalytic domain

MMP 16 (MT3-MMP) catalytic domain

Item no.	BTZ-30100303
Manufacturer	BioTeZ
Amount	200 ug/1 ml
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Protein Family	Matrix Metalloproteinases, matrixins
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Purity	80%
Product Subcategory	EC 3.4.24.80
Pathway and Disease	Diseases associated with MMP16 include Osteochondrosis. Among its related pathways are Matrix Metalloproteinases and MicroRNAs in cancer.
Description	MMP16 is a endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.
Applications Info	Activation of progelatinase A, Degradation of extracellular Matrix, Screening and evaluation of MMP inhibitors, Antigen standard
Alternate Names	Membrane-Type 3- Matrix Metalloproteinase
Sequence	L T G R K W Q H K H I T Y S I K N V T P K V G D P E T R K A I R R A F D V W Q N V T P L T F E E V P Y S E L E N G K R D V D I T I I F A S G F H G D S S P F D G E G G F L A H A Y F P G P G I G G D T H F D S D E P W T L G N P N H D G N D L F L V A V H E L G H A L G L E H S N D P T A I M A P F Y Q Y M E T D N F K L P N D D L Q G I Q K I Y G P P D K I P P P T R P L P T V P P H R
Accession No	P51512
Composition	50 mM Tris-HCl, pH 7.5, 150 mM NaCl, 5 mM CaCl2, 1 % glycerin, 0.1 % Triton X-100.
Storage	Store at -70C
Target Modification	No
Expression System	E.coli
Product Subtype	protein fragment
Active?	Yes
Tag	untagged
Gene ID	4325
Molecular Weight	23 kDa
Shipping Temp Min	dry ice
Product description long	The catalytic domain of MT3-MMP is produced by activation of a recombinant soluble proform of MT3-MMP purified from E. coli.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	MMP16 (partial)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ug/1 ml

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Delivery expected until 10/30/2025

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