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MMP 2 (Progelatinase A)

MMP 2 (Progelatinase A)

Item no.	BTZ-30100603
Manufacturer	BioTeZ
Amount	200 ug/1 ml
Category	Oncology Neuroscience Neuroinflammation Aging & Neurological Disorders Blastoma Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Protein Family	Matrix Metalloproteinases, matrixins
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Available
Purity	> 95 %
Product Subcategory	EC 3.4.24.24
Pathway and Disease	Diseases associated with MMP2 include Multicentric Osteolysis, Nodulosis, And Arthropathy and Multicentric Osteolysis Of Torg. Among its related pathways are Pathways in cancer and Integrin Pathway
Description	MMP2 is a ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly- -Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.
Applications Info	Degradation of extracellular Matrix, Screening and evaluation of MMP inhibitors, Antigen standard
Alternate Names	Matrix Metalloproteinase 2, Progelatinase A, a 72kDa Type IV Collagenase
Sequence	MEALMARGALTGPLRALCLLGCLLSHAAAAPSPII KFPGDVAPKTDKELAVQYLNTFYGCPKESCNLFVL KDTLKMQKFFGLPQTGDLDQNTIETMRKPRCGNPD VANYNFFPRKPKWDKNQITYRIIGYTPDLDPETVD DAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRW EHGDGYPFDGKDGLLAHAFAPGTGVGGDSHFDDDE LWTLGEGQVVRVKYGNADGEYCKFPFLFNGKEYNS CTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFT MGGNAEGQPCKFPFRFQGTYDSCTTEGRTDGYRWC GTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFP FTFLGNKYESCTSAGRSDGKMWCATTANYDDDRKW GFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGALMA PIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGP TPTLGPVTPEICKQDIVFDGIAQIRGEIFFFKDRF IWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAP QEEKAVFFAGNEYWIYSASTLERGYPKPLTSLGLP PDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKK MDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFF KGAYYLKLENQSLKSVKFGSIKSDWLGC
Accession No	P08253
Composition	50 mM Tris-HCl, pH 7.0, 200 mM NaCl, 5 mM CaCl2, 0.05 % Brij-35
Storage	Store at -70C
Target Modification	No
Expression System	Insect Cell
Product Subtype	full length
Active?	Yes, after APMA activation
Tag	untagged
Gene ID	4313
Molecular Weight	72 kDa
Shipping Temp Min	dry ice
Product description long	MMP2 is expressed in Sf9-insect cells using the baculovirus expression vector system and purified from cell culture supernatant.
Purification	Mentioned in the data sheet
Restrictions	For Research Use only.
NCBI Official Symbol	MMP2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 200 ug/1 ml

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Delivery expected until 10/30/2025

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