Anti-TNF-Alpha (Q178) Antibody

Primary Antibodies

25644 MW

WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:200

Tumor necrosis factor

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Cytokine that binds to TNFRSF1A/TNFR1 and
TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can
induce cell death of certain tumor cell lines. It is potent
pyrogen causing fever by direct action or by stimulation of
interleukin-1 secretion and is implicated in the induction of
cachexia, Under certain conditions it can stimulate cell
proliferation and induce cell differentiation. Impairs regulatory
T-cells (Treg) function in individuals with rheumatoid arthritis
via FOXP3 dephosphorylation. Upregulates the expression of protein
phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418'
residue of FOXP3, thereby inactivating FOXP3 and rendering Treg
cells functionally defective (PubMed:23396208). Key mediator of
cell death in the anticancer action of BCG-stimulated neutrophils
in combination with DIABLO/SMAC mimetic in the RT4v6 bladder
cancer cell line (PubMed:22517918).

Boster Bio Anti-TNF-Alpha (Q178) Antibody catalog # A00002. Tested in WB, IHC, IF applications. This antibody reacts with Human, Mouse, Rat.