Anti-TGF Beta 1 (Y369) TGFB1 Antibody

Primary Antibodies

44341 MW

WB: 1:5000-1:10000

Transforming growth factor beta-1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Multifunctional protein that controls proliferation,
differentiation and other functions in many cell types. Many cells
synthesize TGFB1 and have specific receptors for it. It positively
and negatively regulates many other growth factors. It plays an
important role in bone remodeling as it is a potent stimulator of
osteoblastic bone formation, causing chemotaxis, proliferation and
differentiation in committed osteoblasts (By similarity).
Stimulates sustained production of collagen through the activation
of CREB3L1 by regulated intramembrane proteolysis (RIP)
(PubMed:25310401). Can promote either T-helper 17 cells (Th17) or
regulatory T-cells (Treg) lineage differentiation in a
concentration-dependent manner. At high concentrations, leads to
FOXP3-mediated suppression of RORC and down-regulation of IL-17
expression, favoring Treg cell development. At low concentrations
in concert with IL-6 and IL-21, leads to expression of the IL-17
and IL-23 receptors, favoring differentiation to Th17 cells.
Mediates SMAD2/3 activation by inducing its phosphorylation and
subsequent translocation to the nucleus (PubMed:25893292). Can
induce epithelial-to-mesenchymal transition (EMT) and cell
migration in various cell types (PubMed:25893292).

Boster Bio Anti-TGF Beta 1 (Y369) TGFB1 Antibody catalog # A00019Y369. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.