Anti-Rb (phospho-S780) RB1 Antibody

Primary Antibodies

106159 MW

IHC: 1:50-1:200
IF: 1:50-1:200

Retinoblastoma-associated protein

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Key regulator of entry into cell division that acts as a
tumor suppressor. Promotes G0-G1 transition when phosphorylated by
CDK3/cyclin-C. Acts as a transcription repressor of E2F1 target
genes. The underphosphorylated, active form of RB1 interacts with
E2F1 and represses its transcription activity, leading to cell
cycle arrest. Directly involved in heterochromatin formation by
maintaining overall chromatin structure and, in particular, that
of constitutive heterochromatin by stabilizing histone
methylation. Recruits and targets histone methyltransferases
SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional
repression. Controls histone H4 'Lys-20' trimethylation. Inhibits
the intrinsic kinase activity of TAF1. Mediates transcriptional
repression by SMARCA4/BRG1 by recruiting a histone deacetylase
(HDAC) complex to the c-FOS promoter. In resting neurons,
transcription of the c-FOS promoter is inhibited by BRG1-dependent
recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium
influx, RB1 is dephosphorylated by calcineurin, which leads to
release of the repressor complex (By similarity).

Boster Bio Anti-Rb (phospho-S780) RB1 Antibody catalog # A00039S780. Tested in IHC, IF applications. This antibody reacts with Human, Mouse, Rat.