Anti-RAC1 (phospho-S71) Antibody

Primary Antibodies

21450 MW

WB: 1:500-1:2000

Ras-related C3 botulinum toxin substrate 1

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Plasma membrane-associated small GTPase which cycles
between active GTP-bound and inactive GDP-bound states. In its
active state, binds to a variety of effector proteins to regulate
cellular responses such as secretory processes, phagocytosis of
apoptotic cells, epithelial cell polarization, neurons adhesion,
migration and differentiation, and growth-factor induced formation
of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active
component of the cytosolic factor sigma 1, which is involved in
stimulation of the NADPH oxidase activity in macrophages.
Essential for the SPATA13-mediated regulation of cell migration
and adhesion assembly and disassembly. Stimulates PKN2 kinase
activity. In concert with RAB7A, plays a role in regulating the
formation of RBs (ruffled borders) in osteoclasts. In podocytes,
promotes nuclear shuttling of NR3C2; this modulation is required
for a proper kidney functioning. Required for atypical chemokine
receptor ACKR2-induced LIMK1-PAK1-dependent phosphorylation of
cofilin (CFL1) and for up-regulation of ACKR2 from endosomal
compartment to cell membrane, increasing its efficiency in
chemokine uptake and degradation. In synapses, seems to mediate
the regulation of F-actin cluster formation performed by SHANK3.

Boster Bio Anti-RAC1 (phospho-S71) Antibody catalog # A00041S71. Tested in WB applications. This antibody reacts with Human, Rat.