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Anti-Phospho-Caspase-1 (S376) CASP1 Antibody

Anti-Phospho-Caspase-1 (S376) CASP1 Antibody

Item no.	BOS-A00048S376
Manufacturer	Boster
Amount	100 ul
Category	Neuroscience Neural Signaling Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Immunostaining
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	Caspase-1,CASP-1,3.4.22.36,Interleukin-1 beta convertase,IL-1BC,Interleukin-1 beta-converting enzyme,ICE,IL-1 beta-converting enzyme,p45,Caspase-1 subunit p20,Caspase-1 subunit p10,CASP1,IL1BC,IL1BCE
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	45159 MW
Clonality	Polyclonal
Application Details	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:20000 IF 1:50-200
Gene Name	CASP1
Gene Full Name	Caspase-1
Immunogen	The antiserum was produced against synthesized peptide derived from human Caspase 1 around the phosphorylation site of Ser376. AA range:342-391
Contents	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Protein Name	Caspase-1
Protein Function	Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive (PubMed:28314590).
Subcellular Localization	Cytoplasm.
Description	Boster Bio Anti-Phospho-Caspase-1 (S376) CASP1 Antibody catalog # A00048S376. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.
Short Description	Boster Bio Anti-Phospho-Caspase-1 (S376) CASP1 Antibody catalog # A00048S376. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A00048S376-datasheet.pdf

BOS-A00048S376-safety-datasheet.pdf