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Anti-Phospho-p21 (T145) CDKN1A Antibody

Anti-Phospho-p21 (T145) CDKN1A Antibody

Item no.	BOS-A00145T145-1
Manufacturer	Boster
Amount	100 ul
Category	Oncology By Cell Type Carcinoma Hematology Lymphoma Melanoma Sarcoma Cell Biology Cell Status Apoptosis Immunohistochemistry Western Blot ELISA Immunofluorescence Senescence By Organ Lung Cancer Immunostaining
Format	Liquid
Applications	WB, IF, IHC, ELISA
Specific against	Human (Homo sapiens), Mouse (Murine, Mus musculus), Rat (Rattus norvegicus)
Host	Rabbit
Isotype	IgG
Alias	Cyclin-dependent kinase inhibitor 1,CDK-interacting protein 1,Melanoma differentiation-associated protein 6,MDA-6,p21,CDKN1A,CAP20,CDKN1,CIP1,MDA6,PIC1,SDI1,WAF1
Available
Manufacturer - Category	Primary Antibodies
Storage Conditions	Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight	18119 MW
Clonality	Polyclonal
Application Details	WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:10000 IF 1:50-200
Gene Name	CDKN1A
Gene Full Name	Cyclin-dependent kinase inhibitor 1
Immunogen	The antiserum was produced against synthesized peptide derived from human p21 Cip1 around the phosphorylation site of Thr145. AA range:111-160
Contents	Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration	1 mg/ml
Protein Name	Cyclin-dependent kinase inhibitor 1
Protein Function	May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
Subcellular Localization	Cytoplasm. Nucleus.
Description	Boster Bio Anti-Phospho-p21 (T145) CDKN1A Antibody catalog # A00145T145-1. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.
Tissue Specificity	Expressed in all adult tissues, with 5-fold lower levels observed in the brain.
Short Description	Boster Bio Anti-Phospho-p21 (T145) CDKN1A Antibody catalog # A00145T145-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

BOS-A00145T145-1-datasheet.pdf

BOS-A00145T145-1-safety-datasheet.pdf