Comparison

Anti-Bax (S4) Antibody European Partner

Item no. BOS-A00183S4
Manufacturer Boster
Amount 100 ul
Category
Format Liquid
Applications WB, IP, IHC
Specific against Human (Homo sapiens)
Host Rabbit
Alias Apoptosis regulator BAX,Bcl-2-like protein 4,Bcl2-L-4,BAX,BCL2L4
Available
Manufacturer - Category
Primary Antibodies
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Molecular Weight
21184 MW
Clonality
Polyclonal
Application Details
WB: 1:500-1:1000
IHC: 1:50-1:200
IP: 1:50-1:200
Gene Name
BAX
Gene Full Name
Apoptosis regulator BAX
Immunogen
Synthetic peptide, corresponding to the N-terminus of Human Bax.
Contents
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Concentration
1 mg/ml
Protein Name
Apoptosis regulator BAX
Protein Function
Plays a role in the mitochondrial apoptotic process.
Under normal conditions, BAX is largely cytosolic via constant
retrotranslocation from mitochondria to the cytosol mediated by
BCL2L1/Bcl-xL, which avoids accumulation of toxic BAX levels at
the mitochondrial outer membrane (MOM) (PubMed:21458670). Under
stress conditions, undergoes a conformation change that causes
translocation to the mitochondrion membrane, leading to the
release of cytochrome c that then triggers apoptosis. Promotes
activation of CASP3, and thereby apoptosis.
Subcellular Localization
Isoform Alpha: Mitochondrion membrane;
Single-pass membrane protein. Cytoplasm
Description
Boster Bio Anti-Bax (S4) Antibody catalog # A00183S4. Tested in WB, IHC, IP applications. This antibody reacts with Human.
Tissue Specificity
Expressed in a wide variety of tissues.
Isoform Psi is found in glial tumors. Isoform Alpha is expressed
in spleen, breast, ovary, testis, colon and brain, and at low
levels in skin and lung. Isoform Sigma is expressed in spleen,
breast, ovary, testis, lung, colon, brain and at low levels in
skin. Isoform Alpha and isoform Sigma are expressed in pro-
myelocytic leukemia, histiocytic lymphoma, Burkitt's lymphoma, T-
cell lymphoma, lymphoblastic leukemia, breast adenocarcinoma,
ovary adenocarcinoma, prostate carcinoma, prostate adenocarcinoma,
lung carcinoma, epidermoid carcinoma, small cell lung carcinoma
and colon adenocarcinoma cell lines.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ul
Available: In stock
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