Anti-Transforming protein RhoA RhoA Antibody

Primary Antibodies

21768 MW

WB: 1:1, 000-1:2, 000
ICC: 1:50-1:200
FC: 1:50-1:100

Transforming protein RhoA

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Regulates a signal transduction pathway linking plasma
membrane receptors to the assembly of focal adhesions and actin
stress fibers. Involved in a microtubule-dependent signal that is
required for the myosin contractile ring formation during cell
cycle cytokinesis. Plays an essential role in cleavage furrow
formation. Required for the apical junction formation of
keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity.
May be an activator of PLCE1. Activated by ARHGEF2, which promotes
the exchange of GDP for GTP. Essential for the SPATA13-mediated
regulation of cell migration and adhesion assembly and
disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an
important role in ERBB2-dependent stabilization of microtubules at
the cell cortex. It controls the localization of APC and CLASP2 to
the cell membrane, via the regulation of GSK3B activity. In turn,
membrane-bound APC allows the localization of the MACF1 to the
cell membrane, which is required for microtubule capture and
stabilization. Regulates a signal transduction pathway linking
plasma membrane receptors to the assembly of focal adhesions and
actin stress fibers. Involved in a microtubule-dependent signal
that is required for the myosin contractile ring formation during
cell cycle cytokinesis. Plays an essential role in cleavage furrow
formation. Required for the apical junction formation of
keratinocyte cell-cell adhesion. May be an activator of PLCE1.
Activated by ARHGEF2, which promotes the exchange of GDP for GTP.
Essential for the SPATA13-mediated regulation of cell migration
and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1
signaling pathway plays an important role in ERBB2-dependent
stabilization of microtubules at the cell cortex. It controls the
localization of APC and CLASP2 to the cell membrane, via the
regulation of GSK3B activity. In turn, membrane-bound APC allows
the localization of the MACF1 to the cell membrane, which is
required for microtubule capture and stabilization (By
similarity). Regulates KCNA2 potassium channel activity by
reducing its location at the cell surface in response to CHRM1
activation; promotes KCNA2 endocytosis (PubMed:9635436,
PubMed:19403695).

Boster Bio Anti-Transforming protein RhoA RhoA Antibody catalog # A00207-2. Tested in WB, ICC/IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.