Anti-Caspase-3 CASP3 Antibody

Primary Antibodies

31608 MW

Caspase-3 antibody can be used for detection of Caspase-3 by immunohistochemistry at 5 μg/mL.
Antibody validated: Immunohistochemistry in human samples. All other applications and species not yet tested. Optimal dilutions for each application should be determined by the researcher.

Caspase 3, apoptosis-related cysteine peptidase

Caspases are a family of cysteine proteases that can be divided into the apoptotic and inflammatory caspase subfamilies. Unlike the apoptotic caspases, members of the inflammatory subfamily are generally not involved in cell death but are associated with the immune response to microbial pathogens. The apoptotic subfamily can be further divided into initiator caspases, which are activated in response to death signals, and executioner caspases, which are activated by the initiator caspases and are responsible for cleavage of cellular substrates that ultimately lead to cell death. Caspase-3 is synthesized as an inactive proenzyme that undergoes proteolytic cleavage by caspases 8, 9 and 10 to produce 2 subunits, termed p20 and p11. These subunits dimerize to form the active enzyme. Caspase-3 proteolytically cleaves and activates other proteins such as caspases 6, 7 and 9.

Caspase-3 Antibody is supplied in PBS containing 0.02% sodium azide.

1 mg/mL

Caspase 3, apoptosis-related cysteine peptidase

Cytoplasm.

Highly expressed in lung, spleen, heart, liver
and kidney. Moderate levels in brain and skeletal muscle, and low
in testis. Also found in many cell lines, highest expression in
cells of the immune system.

At least two isoforms of Caspase-3 are known to exist.