Anti-APG7 ATG7 Antibody

APG7 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Polyclonal

ATG7

At least three isoforms of APG7 are known to exist; this antibody will detect all three isoforms. APG7 antibody is predicted not to cross-react with other ATG family proteins.

APG7 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human APG7. The immunogen is located within amino acids 590 - 640 of APG7.

APG7 Antibody is affinity chromatography purified via peptide column.

Apoptosis, Autophagy

E1-like activating enzyme involved in the 2 ubiquitin-
like systems required for cytoplasm to vacuole transport (Cvt) and
autophagy. Activates ATG12 for its conjugation with ATG5 as well
as the ATG8 family proteins for their conjugation with
phosphatidylethanolamine. Both systems are needed for the ATG8
association to Cvt vesicles and autophagosomes membranes. Required
for autophagic death induced by caspase-8 inhibition. Required for
mitophagy which contributes to regulate mitochondrial quantity and
quality by eliminating the mitochondria to a basal level to
fulfill cellular energy requirements and preventing excess ROS
production. Modulates p53/TP53 activity to regulate cell cycle and
survival during metabolic stress. Plays also a key role in the
maintenance of axonal homeostasis, the prevention of axonal
degeneration, the maintenance of hematopoietic stem cells, the
formation of Paneth cell granules, as well as in adipose
differentiation. Plays a role in regulating the liver clock and
glucose metabolism by mediating the autophagic degradation of CRY1
(clock repressor) in a time-dependent manner (By similarity).

Boster Bio Anti-APG7 ATG7 Antibody (Catalog # A00346-1). Tested in ELISA, WB, ICC, IF applications. This antibody reacts with Human, Mouse.

Chicken, Rat