Anti-ATG7 Antibody

Primary Antibodies

77960 MW

IHC: 1:50-1:200
ICC/IF: 1:50-1:200

Ubiquitin-like modifier-activating enzyme ATG7

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

E1-like activating enzyme involved in the 2 ubiquitin-
like systems required for cytoplasm to vacuole transport (Cvt) and
autophagy. Activates ATG12 for its conjugation with ATG5 as well
as the ATG8 family proteins for their conjugation with
phosphatidylethanolamine. Both systems are needed for the ATG8
association to Cvt vesicles and autophagosomes membranes. Required
for autophagic death induced by caspase-8 inhibition. Required for
mitophagy which contributes to regulate mitochondrial quantity and
quality by eliminating the mitochondria to a basal level to
fulfill cellular energy requirements and preventing excess ROS
production. Modulates p53/TP53 activity to regulate cell cycle and
survival during metabolic stress. Plays also a key role in the
maintenance of axonal homeostasis, the prevention of axonal
degeneration, the maintenance of hematopoietic stem cells, the
formation of Paneth cell granules, as well as in adipose
differentiation. Plays a role in regulating the liver clock and
glucose metabolism by mediating the autophagic degradation of CRY1
(clock repressor) in a time-dependent manner (By similarity).

Boster Bio Anti-ATG7 Antibody catalog # A00346-3. Tested in IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.