Anti-sRANK Ligand TNFSF11 Antibody

Primary Antibodies

35478 MW

WB: 0.25-4 μg/mL; IHC: 5 μg/mL.
Antibody validated: Western Blot in human, mouse and rat samples; Immunohistochemistry in human and rat samples. All other applications and species not yet tested.
Optimal dilutions for each application should be determined by the researcher.

Tumor necrosis factor (ligand) superfamily, member 11

Anti-sRANK-L antibody was raised against a peptide corresponding to 14 amino acids near the center of human sRANK-L. The immunogen is located within amino acids 140-190 of sRANK-L.

sRANK Ligand Antibody is affinity chromatography purified via peptide column.

Apoptosis

Cytokine that binds to TNFRSF11B/OPG and to
TNFRSF11A/RANK. Osteoclast differentiation and activation factor.
Augments the ability of dendritic cells to stimulate naive T-cell
proliferation. May be an important regulator of interactions
between T-cells and dendritic cells and may play a role in the
regulation of the T-cell-dependent immune response. May also play
an important role in enhanced bone-resorption in humoral
hypercalcemia of malignancy (PubMed:22664871). Induces
osteoclastogenesis by activating multiple signaling pathways in
osteoclast precursor cells, chief among which is induction of long
lasting oscillations in the intracellular concentration of Ca (2+)
resulting in the activation of NFATC1, which translocates to the
nucleus and induces osteoclast-specific gene transcription to
allow differentiation of osteoclasts. During osteoclast
differentiation, in a TMEM64 and ATP2A2-dependent manner induces
activation of CREB1 and mitochondrial ROS generation necessary for
proper osteoclast generation (By similarity).

Boster Bio Anti-sRANK Ligand TNFSF11 Antibody (Catalog # A00363-1). Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human, Mouse, Rat.