Anti-TRAF2 (S11) Antibody

Primary Antibodies

55859 MW

WB: 1:500-1:1000

TNF receptor-associated factor 2

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Regulates activation of NF-kappa-B and JNK and plays a
central role in the regulation of cell survival and apoptosis.
Required for normal antibody isotype switching from IgM to IgG.
Has E3 ubiquitin-protein ligase activity and promotes 'Lys-63'-
linked ubiquitination of target proteins, such as BIRC3, RIPK1 and
TICAM1. Is an essential constituent of several E3 ubiquitin-
protein ligase complexes, where it promotes the ubiquitination of
target proteins by bringing them into contact with other E3
ubiquitin ligases. Regulates BIRC2 and BIRC3 protein levels by
inhibiting their autoubiquitination and subsequent degradation;
this does not depend on the TRAF2 RING-type zinc finger domain.
Plays a role in mediating activation of NF-kappa-B by EIF2AK2/PKR.
In complex with BIRC2 or BIRC3, promotes ubiquitination of IKBKE.

Boster Bio Anti-TRAF2 (S11) Antibody catalog # A00400S11. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.