Anti-Integrin Alpha 4 ITGA4 Antibody

Primary Antibodies

114900 MW

WB: 1:500-1:2000
IHC: 1:50-1:100

Integrin alpha-4

Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2

1 mg/ml

Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are
receptors for fibronectin. They recognize one or more domains
within the alternatively spliced CS-1 and CS-5 regions of
fibronectin. They are also receptors for VCAM1. Integrin alpha-
4/beta-1 recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-
4/beta-7 is also a receptor for MADCAM1. It recognizes the
sequence L-D-T in MADCAM1. On activated endothelial cells integrin
VLA-4 triggers homotypic aggregation for most VLA-4-positive
leukocyte cell lines. It may also participate in cytolytic T-cell
interactions with target cells. ITGA4:ITGB1 binds to fractalkine
(CX3CL1) and may act as its coreceptor in CX3CR1-dependent
fractalkine signaling (PubMed:23125415). ITGA4:ITGB1 binds to
PLA2G2A via a site (site 2) which is distinct from the classical
ligand-binding site (site 1) and this induces integrin
conformational changes and enhanced ligand binding to site 1
(PubMed:18635536, PubMed:25398877).

Boster Bio Anti-Integrin Alpha 4 ITGA4 Antibody catalog # A00468-1. Tested in WB, IHC applications. This antibody reacts with Human, Mouse, Rat.