Anti-ULK1 Antibody

ULK1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Polyclonal

ULK1

Two alternatively spliced transcript variants encoding different isoforms have been identified. ULK1 antibody is predicted to not cross-react with ULK2.

ULK1 antibody was raised against a 16 amino acid peptide near the center of human ULK1. The immunogen is located within amino acids 350 - 400 of ULK1.

ULK1 Antibody is affinity chromatography purified via peptide column.

Autophagy

Serine/threonine-protein kinase involved in autophagy in
response to starvation. Acts upstream of phosphatidylinositol 3-
kinase PIK3C3 to regulate the formation of autophagophores, the
precursors of autophagosomes. Part of regulatory feedback loops in
autophagy: acts both as a downstream effector and negative
regulator of mammalian target of rapamycin complex 1 (mTORC1) via
interaction with RPTOR. Activated via phosphorylation by AMPK and
also acts as a regulator of AMPK by mediating phosphorylation of
AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively
regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and
RPTOR; however such data need additional evidences. Plays a role
early in neuronal differentiation and is required for granule cell
axon formation. May also phosphorylate SESN2 and SQSTM1 to
regulate autophagy (PubMed:25040165).

Boster Bio Anti-ULK1 Antibody (Catalog # A00584). Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

Two alternatively spliced transcript variants encoding different isoforms have been identified. ULK1 antibody is predicted to not cross-react with ULK2.